Rapid maxillary expansion (RME) is an orthodontic treatment commonly used in children to correct skeletal transverse problems of the maxilla. This clinical report introduces an effective way to diagnose and treat skeletal transverse problems achieving an orthopedic response, therby reducing dental tipping and the need to overcorrect. Two clinical cases are used to illustrate an accurate skeletal diagnosis of the transverse dimension, orthopedic treatment using RME and a rationale for early orthodontic intervention.